Interactions

prepareCisPairs()

Prepares motif pairs as GInteractions and add genomic features.

getCisPairs()

Build a GInteractions object with all pairs of input GRanges within a given distance.

addStrandCombination()

Add combination of anchor strand orientation.

addMotifScore()

Add motif score of anchors.

addInteractionSupport()

Add column to GInteractions with overlap support.

addCor()

Add correlation of ChIP-seq coverage to motif pairs.

addCovCor()

Add correlation of anchor signals to pairs of close genomic regions.

Reading genomic data

addCovToGR()

Add coverage to regions in GRanges object.

parseLoopsRao()

Parse chromatin loops from Rao et al. 2014 as strict GInteractions.

parseLoopsTang()

Parse chromatin interactions from Tang et al. 2015 as GInteractions.

Prediction

predLoops()

Predict looping interactions.

Data sets

motif.hg19.CTCF

CTCF motif locations in human genome hg19.

motif.hg19.CTCF.chr22

CTCF motif locations on chromosome 22 in human genome hg19.

motif.hg19.CTCF.chr22.cov

CTCF motifs on human chromosome 22 with example coverage.

modelBest10Avg

Default parameters for logistic regression model in sevenC.

TFspecificModels

TF specific parameters for logistic regression in sevenC

cutoffByTF

Optimal cutoff values for logistic regression models.

cutoffBest10

Default optimal cutoff value of logistic regression.