Declarations

Availability of data and material

The source code of all analysis is available on GitHub: https://github.com/Juppen/TAD-Evolution. All the genomic data used for analyses are freely available to be downloaded from the UCSC Genome Browser and EBI Expression Atlas with identifiers listed in Table 3.1 and Table S1.

Competing interests

The authors declare that they have no competing interests.

Authors‘ contributions

JK and JI developed and implemented the methods and performed the analysis. JI conceived the study. JK wrote the first draft of the manuscript. JK, MA and JI wrote the manuscript. MA supervised the study.

Acknowledgments

The authors thank all members of the CBDM group for fruitful discussions.